This presentation will focus on lifting learning potential through learning science based instructional practices and reading intervention. The session will cover new brain science and outcome research on data-driven robust individualized approaches to intervention. The emphasis will be on review of intervention approaches that consider SEL and ELL factors. Also covered will be the importance recognizing and providing the resources required for full implementation and long-term sustainability. The presentation will include urban district-wide evidence on classroom instructional practices and neuroscience-based interventions shown to meet both students' learning and behavioral needs. It will also provide resources for teachers and other personnel. Finally, it will include an emphasis on equity as an important consideration for determining best practices for reading intervention.